ERG oncoprotein expression in prostate carcinoma patients of different ethnicities
نویسندگان
چکیده
منابع مشابه
ERG oncoprotein inhibits ANXA2 expression and function in prostate cancer.
UNLABELLED Overexpression of ERG in the prostate epithelium, due to chromosomal translocations, contributes to prostate tumorigenesis. Here, genomic analysis of ERG siRNA-treated prostate cells harboring the endogenous TMPRSS2-ERG fusion revealed an inverse relationship between ERG and Annexin A2 (ANXA2) expression at both the RNA and protein level. ANXA2, a Ca(2+)-dependent and phospholipid-bi...
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Abstract Introduction: Colorectal cancer is the third most prevalent malignancy with high mortality rate, necessitating markers that predict survival and guide the treatment. Previous studies have examined the immunohistochemical expression of Bcl-2, an apoptotic marker, in colorectal carcinoma, but results have been contradictory. Objectives: To evaluate the histopathological featu...
متن کاملExpression of ERG Protein and TMRPSS2-ERG Fusion in Prostatic Carcinoma in Egyptian Patients
AIM Prostate cancer (PCa) is the second most common cancers in men worldwide. Its incidence can be influenced by several risk factors including genetic susceptibility. Therefore the search for the expression of a certain gene (ERG) and its rearrangement could give us clues for proper identification of PCa. And the study of ERG expression and its comparison to FISH in Egyptian patients can show ...
متن کاملPeripheral refraction in different ethnicities.
PURPOSE Peripheral refraction is commonly used to infer retinal shape. Because of the different prevalence of myopia in the white compared with East Asian populations, peripheral refraction along the horizontal meridian was compared in white and East Asian young adults with emmetropic, low myopic, and moderately myopic refractive errors. METHODS Thirty-five white and 37 East Asian subjects we...
متن کاملStudy the Expression of CD10 in Prostate Carcinoma and its Correlation with Various Clinicopathological Parameters
Background and Objective: Adenocarcinoma of the prostate is the second most common cause of cancer. The loss of CD10 is a common early event in human prostate cancer and is seen in lower Gleason Score malignancies while increased and altered expression is seen in high Gleason Score tumors, lymph nodes and bone metastasis. Material and Methods: This was a ...
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ژورنال
عنوان ژورنال: Molecular and Clinical Oncology
سال: 2014
ISSN: 2049-9450,2049-9469
DOI: 10.3892/mco.2014.418